investigate how hypertension develops and find new and effective principles for how to prevent and treat the disease. These techniques are used to investigate the sensing step in the TGF, the modulation step in the mesangial cells and the calcium release and contractile response of the arterioles. Our group studies how hormones and other factors,.g. In collaborations with physicians at different hospitals we have clinical trials to investigate the potential role of oxidative stress and NO-deficiency in CVD.
Erik Larsson, Uppsala universitet.
Kontakta katalogansvarig vid den aktuella organisationen (institution eller motsv.) f r att r tta.
St Olofsgatan uppsala restaurang, Buss från östhammar till uppsala, Matskola 4h uppsala, Swecon anläggningsmaskiner ab uppsala,
Renal renin release is controlled via the avstängda gator stockholm maraton same mechanism. We also employ isolated perfused tubule and arteriole techniques using fluorophores and digital imaging methods to determine calcium, chloride and NO in the macula densa cells and in the arteriolar smooth muscle cells. In the macula densa cells, located in the distal part of the nephron, the fluid flow rate is sensed. L-arginine or nitrate supplementation). One factor of great importance in regulation of fluid excretion is the tubuloglomerular feedback (TGF) control mechanism. Unfortunately, these risk factors are only partly reduced during treatment with the existing drugs. Reduction of renal oxidative stress may increase nitric oxide (NO) bioavailability and thereby play an important role in preventing and/or treating CVD. For the fluid balance and blood pressure level in the body, the renal control of fluid excretion rate is essential. We have advanced equipment for investigating renal and cardiovascular function, and imaging systems for measuring oxidative stress and NO production (in vivo and in vitro). We believe that treatment strategies aiming to reduce oxidative stress and/or increase NO-bioavailability could be of great value in the future to treat hypertension to prevent stroke and cardio-vascular disease. For further information about this research group please contact Professor Erik Persson.
The juxtamedullary nephron preparation is used to visualise afferent arteriolar endothelial cells to measure calcium and. Antioxidant, nitroxide, low-sodium treatment) or increasing NO production (e.g. Activation of the TGF mechanism finally leads to a contraction of the afferent arteriole.